Table 5 Results of causal association analysis of differential gene eQTLs with EC.

Exposure	Outcome	Nsnp	MR	P	I2(%)	Heterogeneity	P	Egger intercept	Horizontal pleiotropy		MR-PRESSO	Steiger
Exposure	Outcome	Nsnp	OR(95%CI)	P	I2(%)	Cochran’s Q	P	Egger intercept	SE	P	P	Correct_causal_direction
CDKN2A	EC	6	1.546 (1.298–1.842)	< 0.001	12	5.675	0.339				0.391	TRUE
CDKN2A	EC	6	1.322 (0.654–2.673)	0.48	26	5.399	0.249	0.014	0.032	0.675
CDKN2A	EC	6	1.608 (1.276–2.025)	< 0.001
CDKN2A	EC	6	1.678 (1.142–2.465)	0.046
CDKN2A	EC	6	1.649 (1.137–2.392)	0.046
DDA1	EC	19	1.111 (1.021–1.208)	0.014	0	16.632	0.549				0.607	TRUE
DDA1	EC	19	1.306 (1.042–1.635)	0.033	0	14.333	0.643	-0.02	0.013	0.148
DDA1	EC	19	1.093 (0.970–1.230)	0.144
DDA1	EC	19	1.112 (0.909–1.359)	0.315

Exposure	Outcome	Nsnp	MR			Heterogeneity			Horizontal pleiotropy		MR-PRESSO	Steiger
DDA1	EC	19	1.103 (0.940–1.293)	0.245
LRRC42	EC	18	1.112 (1.026–1.206)	0.01	0	16.78	0.469				0.491	TRUE
LRRC42	EC	18	1.165 (0.993–1.367)	0.079	2	16.331	0.43	-0.007	0.01	0.516
LRRC42	EC	18	1.100 (0.971–1.245)	0.133
LRRC42	EC	18	1.045 (0.846–1.290)	0.69
LRRC42	EC	18	1.076 (0.927–1.249)	0.349
POLB	EC	18	1.072 (1.004–1.145)	0.038	0	13.629	0.693				0.744	TRUE
POLB	EC	18	0.967 (0.864–1.084)	0.574	0	8.845	0.92	0.023	0.01	0.044
POLB	EC	18	1.045 (0.953–1.146)	0.349
POLB	EC	18	1.046 (0.923–1.185)	0.494
POLB	EC	18	1.048 (0.954–1.152)	0.339

Quick links

Search