Fig. 14

MiR-125b-5p inhibits ferroptosis by targeting the Keap1/Nrf2/GPX4 axis, thereby alleviating MS-induced injury cell. (A) ROS detected by immunofluorescence in MS-induced injury cell model. Green: ROS. Magnification: 40x. Detection of biochemical indicators of GSH (B), MDA (C) and total iron (D) in MS-induced injury cell models. (**P < 0.01. ****P < 0.0001). MS, mechanical stretch; ROS, Reactive oxygen species; GSH, Glutathione; MDA, malondialdehyde.