Table 1 A comparison of related works concerning malaria diagnosis using AI techniques.

From: Automated multi-model framework for malaria detection using deep learning and feature fusion

Study

Year

Dataset

Method

Results

Pros

Cons

Muhammad et al.11

2025

772 (616 + 156) images for rouleaux morphology and 772 for normal morphology

XceptionNet, ResNet 50, DenseNet, EfficientNetB4, customized CNN

Accuracy 99% for DeseNet-201

Rouleaux formation morphology of the RBCs is detected with DL algorithms.

Unbalance of Giemsa-stained images with field-stained images.

Ozsahin et al.3

2024

Related to 2207 patients

MLR, ANN, ANFIS, and RF

Model performance is evaluated in R, R2, RMSE, and MSE

Developing hybrid ML models for malaria diagnosis.

Using only ML algorithms. Generalization of the approach is limited.

Hoyos and Hoyos6

2024

222 original images and

666 augmented images

YOLOv8

An accuracy of 91% for original images and 95% for augmented images

Detecting malaria parasites and leukocytes with high accuracy.

Low diversity of trained images. Low number of used datasets.

Khan et al.2

2024

12,500 augmented microscopic images

R-CNN & ResNet- 18, 50, 101, 152 & GoogleNet

R-CNN outperformed the other classifiers with an accuracy of 91.21%

A novel framework was presented for malaria detection.

Cell morphological changes were not considered.

Hemachandran et al.14

2023

27,558 microscopic images

CNN & ResNet-50 & MobileNet-V2

MobileNet-V2 outperformed by an accuracy of 97%.

Comparing the performance of many DL models on a large dataset.

A traditional CNN was used.

Muhammad et al.10

2023

51 images (rouleaux morphology) and 180 images (normal morphology)

Customized CNN for normal morphology and rouleaux morphology

Accuracy: 90.95% (300 × 300) & 87.75% (500 × 500)

Evaluating the CNN performance in detecting abnormal cell morphology across varying image sizes.

A relatively low number of images (6088).

Shallow depth of CNN layers (5 layers)

Ozsahin et al.15

2022

300 infected thick smear images and 319 thin smear images

Customized CNN, ResNet-50, VGG16, and Inception V3

Best performance of thick smear images with an accuracy of 96.97%.

Developing a novel model for malaria diagnosis based on DL techniques.

Relative law number of images.

Sunarko et al.1

2020

Related to 150 infected patients and 50 healthy patients (2000 images)

Otsu’s method + K -clustering

Accuracy: 94.6%

Specificity:96.2%

Sensitivity: 93%

A threshold-based segmentation method was adopted for malaria diagnosis.

Low amount of data.

Detecting parasites in schizont stage is limited.

Kassim et al.13

2020

Polygen set was 34,226 RBC, and point set was 162,443 RBC

RBCNet based on U-Net and faster R-CNN

Cell detection with an accuracy of over 97%

A novel DL algorithm was presented for the RBCs segmentation using a large dataset.

No classification of infected and non-infected cells.