Table 14 Comparing results (%) against the sate-of-the-art (SOTA) for each CYP isoform.

Isoforms	Reference, (Year)	Method	Acc	AUC	Sen	Spe	MCC	F1	Pre
CYP1A2	Njimbouom et al.²⁵, (2024)	MumCypNet	82	90	82	85	64	82	82
	Ai et al.²⁹, (2023)	DEEPCYPs	84	93	82	88	70	82	91
	Qiu et al.³³, (2022)	GCNN	84	92	82	86	68	84	92
	Ngyuyen et al.³⁴ (2021)	iCYP-MFE	81	91	81	81	62	83	83
	Ours, (2024)	MEN	92	96	85	91	69	87	96
CYP2C9	Njimbouom et al.²⁵ (2024)	MumCypNet	80	89	69	91	59	78	88
	Ai et al.²⁹ (2023)	DEEPCYPs	84	91	72	93	66	76	85
	Qiu et al.³³ (2022)	GCNN	76	89	63	92	58	70	79
	Ngyuyen et al.³⁴ (2021)	iCYP-MFE	86	92	72	91	67	80	90
	Ours, (2024)	MEN	94	95	80	95	70	79	92
CYP2C19	Njimbouom et al.²⁵ (2024)	MumCypNet	80	89	76	81	61	77	88
	Ai et al.²⁹ (2023)	DEEPCYPs	78	86	71	84	57	76	81
	Qiu et al.³³ (2022)	GCNN	81	88	77	82	60	76	89
	Ngyuyen et al.³⁴ (2021)	iCYP-MFE	90	90	67	89	68	62	80
	Ours, (2024)	MEN	89	97	79	88	67	78	88
CYP2D6	Njimbouom et al.²⁵ (2024)	MumCypNet	78	86	71	85	57	76	81
	Ai et al.²⁹ (2023)	DEEPCYPs	91	88	64	91	60	65	78
	Qiu et al.³³ (2022)	GCNN	85	92	77	85	66	76	87
	Ngyuyen et al.³⁴ (2021)	iCYP-MFE	82	91	78	84	64	77	86
	Ours, (2024)	MEN	93	91	82	90	69	80	86
CYP3A4	Njimbouom et al.²⁵ (2024)	MumCypNet	87	93	74	86	64	79	89
	Ai et al.²⁹ (2023)	DEEPCYPs	82	90	83	85	64	82	82
	Qiu et al.³³ (2022)	GCNN	84	93	82	88	70	82	91
	Ngyuyen et al.³⁴ (2021)	iCYP-MFE	84	92	82	86	68	84	92
	Ours, (2024)	MEN	92	95	81	89	69	83	94

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