Fig. 2 | Scientific Reports

Fig. 2

From: Evaluation of biological sex on endstage pathobiology and regenerative treatment of volumetric muscle loss

Fig. 2

Assessment of collagen deposition at the VML defect site. (a) Representative picrosirius red-stained muscle cross-sections at the defect site 56 days post-injury, with red indicating collagen and yellow identifying muscle fibers. Scale bars = 200 μm. (b) Quantitative analysis of collagen deposition in VML-injured muscles (n = 5–7 muscles/group). (c) Quantification of COL1 A1 protein levels in VML-injured muscles (n = 8–9 muscles/group). Females and males are represented by red and blue markers, respectively. Data are shown as mean ± SD. Statistical significance is denoted by *(P < 0.05) and **(P < 0.01), determined by two-way ANOVA with Sidak’s post hoc test. NR = no repair; MMG = minced muscle graft.

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