Fig. 3

Progressive truncal instability and reduced speed in β-III^−/− mice compared to age-matched controls. (a) Schematic of different spatial gait parameters obtained with CatWalk XT system: stride length, print position and base of support (BOS). (b) Representative CatWalk XT run for control and β-III^−/− mice aged 18-months. Quantification of (c) average body speed, (d) hind limb base of support and (e) forelimb base of support of control (dark coloured boxes) and β-III^−/− mice (light coloured boxes) at 6–8-weeks (6-8w; blue), 6–8-months (6–8 m; orange)- and 18–20-months of age (18–20 m; green). Progressive decrease in body speed and increase in base of support observed for β-III^−/− mice, compared to age-matched controls (N = 10–16). All data plotted as median, quartiles (25th and 75th percentiles), minimum and maximum with mean indicated by cross. Statistical differences between control and β-III^−/− animals of the same age denoted by *; between β-III^−/− animals of different ages denoted by #; between control animals of different ages denoted by ≠.