Fig. 5 | Scientific Reports

Fig. 5

From: Automated gait analysis indicates efficacy of T-type calcium channel inhibition for mitigation of disrupted calcium signalling in an SCA5 mouse model

Fig. 5

Altered support in β-III−/− mice compared to age-matched controls. (a) Schematic representation of the various paw combinations: single, three, four, diagonal (opposite forepaw and hindpaw), lateral (hind and forepaw on the same side) and girdle (both hind or both forepaws). (b) Box plots showing the average percentage of total run duration spent supported on the different paw combinations for 18–20-month-old animals. β-III−/− mice (light green) spent significantly less time on diagonal paws than controls (dark green) and more time on their lateral, girdle and three paws. Data plotted as median, quartiles (25th and 75th percentiles), minimum and maximum with mean indicated by cross.

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