Fig. 6

Trimethadione improves interlimb coordination in 8-month- old β-III^−/− mice. Quantification of various CatWalk XT parameters for 8-month-old β-III^−/− mice administered trimethadione (TMD) in their drinking water. Data from wildtype animals (WT) matched for sex and age to β-III^−/− mice plotted alongside for comparison. (a) Average body speed. (b) Regularity index. (c, d) Print positions. (e, f) Phase dispersion. (g, h) Percentage of total run duration spent supported on diagonal (g) and three (h) paw combinations. TMD administration significantly improved all parameters, apart from average body speed, for β-III^−/− mice when compared to untreated (UT). Greater interlimb coordination with TMD administration also shown by several parameters no longer being significantly different to WT with improvements to average body speed and diagonal support also evident (N = 6). Data plotted as median, quartiles (25th and 75th percentiles), minimum and maximum with mean indicated by cross.