Fig. 1

Upregulated activities of macrophages in IL-37^hi-TG mice. (A, B) Identification of mouse strains with distinct IL-37 expression. (C) Enhanced frequency of F4/80⁺ and CD11c⁺ cells in IL-37^hi-TG mice. (D-G) Changes of splenic macrophage activities in IL-37^lo-TG and IL-37^hi-TG mice before or after LPS stimulation (F4/80-TNFα, F4/80-CD86, and F4/80-PD-L1, respectively). (H, I) Increased M1 and M2 subsets in IL-37^hi-TG mice, respectively. (J) Upregulated CD8⁺T cell activities in IL-37^hi-TG mice. *P<0.05, **P<0.01, ***P<0.001, ns: not significant.