Fig. 2 | Scientific Reports

Fig. 2

From: High-dose IL-37 promotes inflammatory activity of macrophage via Preferential ligation of the IL-18Rα

Fig. 2

High-dose rIL-37 stimulates macrophage activity. (A, B) Expression of F4/80-TNF-α increased in high-dose rIL-37 groups (100/200/500 ng/ml) and decreased in the low-dose rIL-37 group (10 ng/ml) before and after LPS stimulation by Flow cytometry and ELISA. (C) High doses (100, 200, and 500 ng/ml) of rIL-37 promoted the expression of F4/80-CD86 compared with low doses (1 and 10 ng/ml). (D) No significant change in F4/80-PD-L1 expression at different rIL-37 doses. vs. 0 ng/ml, *P<0.05, **P<0.01, ns: not significant.

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