Fig. 4 | Scientific Reports

Fig. 4

From: High-dose IL-37 promotes inflammatory activity of macrophage via Preferential ligation of the IL-18Rα

Fig. 4

High-dose rIL-37 inhibits STAT3 activation in macrophages. (A-F) High-dose rIL-37 (100 and 200 ng/ml) inhibited the activation of PTEN/STAT3/AMPK signaling pathway. (G-O) High-dose rIL-37 (100 and 200 ng/ml) activated the AKT/Erk/NF-κB/mTOR signaling pathway. (P) Results of Immunofluorescence showed that high-dose rIL-37 (200 ng/ml) preferentially ligate to IL-18Rα receptor instead of IL-1R8 receptor. (Q) Results of flow cytometry confirmed the immunofluorescence finding. *P<0.05, **P<0.01, ***P<0.001.

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