Table 1 Summary of cut-off value or RIs for six coagulation parameters.

From: Reference intervals for coagulation parameters in chinese adults stratified by sex and age

Test (units)

Method

Manufacturers

Groups

Number

Cut-off value/RIs

Definition

LA normalized ratio

Clot-based assays

Stago

NA

27

> 1.20

NA

Werfen

NA

40

> 1.20

Mean + 3SD

Sysmex

Age: 18–55 years

26

> 1.2

NA

Beijing strong

Age: 18–60 years

153

> 1.2

97.5%

Mindray*

Age: 18–65 years

425

> 1.20

99%

Protein S (%)

Clot-based assays

Stago

Age: 18–65 years

156

NA

NA

Male

94

77–143%

Female

62

55–123%

Werfen

NA

164

63.5–149.0%

NA

Siemens

Overall

218

60–130%

5–95%

Male

NA

75–130%

Female/Non-fertility drug user

NA

59–118%

Female/Fertility drug user

NA

52–118%

Mindray*

Age: 18–65 years

448

64.0–134.1%

2.5–97.5%

Male

203

73.0–136.3%

Female

245

57.7–122.6%

Protein C (%)

Chromogenic substrate assays

Stago

Adult

NA

70–130%

NA

Werfen

NA

NA

70–140%

NA

Siemens

NA

NA

70–140%

NA

Mindray*

Age: 18–65 years

448

68.1–143.1%

2.5–97.5%

Age: 18–50 years

303

68.5–137.6%

Age: 51–65 years

145

67.3–145.1%

Factor VIII (%)

Clot-based assays

Stago

Adult

NA

60–150%

NA

Werfen

NA

NA

50–150%

NA

Siemens

NA

NA

70–150%

NA

Mindray*

Age: 18–65 years

448

58.1–157.5%

2.5–97.5%

Age: 18–35 years

170

54.4–151.4%

Age: 36–50 years

133

63.6–156.0%

Age: 51–65 years

145

71.2–158.1%

Factor IX (%)

Clot-based assays

Stago

Adult

NA

60–150%

NA

Werfen

NA

NA

65–150%

NA

Siemens

NA

NA

70–120%

NA

Mindray*

Age: 18–65 years

448

70.5–152.2%

2.5–97.5%

vWF Ag (%)

Immunoturbidimetry

Stago

Adult

NA

50–160%

NA

Werfen

Overall

252

NA

NA

Blood type O

126

42.0–140.8%

Blood type A + B + AB

126

66.1–176.3%

Siemens

Adult

NA

50–160%

NA

Mindray*

Age: 18–65 years

448

53.1–176.1%

2.5–97.5%

Age: 18–35 years

170

45.4–162.6%

Age: 36–50 years

133

60.3–176.2%

Age: 51–65 years

145

69.5–181.9%

  1. NA: Not available.
  2. *The manufacturer’s reagent kits used in this study.