Fig. 2

Multivariate-adjusted relationships between plasma TMAO and ASCVD evaluated using restricted cubic splines. Knots were evaluated at the 10th, 50th, and 90th percentiles. Dotted vertical lines represent, from left to right, the 10th, 25th, 50th, 75th, and 90th percentiles of circulating TMAO. Covariates are specified in Table 2. The top 1% of the exposure distribution was omitted for better visualization.