Fig. 4 | Scientific Reports

Fig. 4

From: Potentiation of immune checkpoint blockade with an ITPP radiosensitizer studied with oxygen saturation measurements from photoacoustic imaging

Fig. 4

ITPP increased oxygen delivery to 4T1 tumors. (a) A study timeline. PAI was performed 3 h after administering ITPP. Mice were euthanized after the last PAI scan. (b) The %sO2 distribution maps of 4T1 tumors subcutaneously implanted in female Balb/cJ mice, subdivided by treatment. (c) The change in %sO2 throughout the treatment period of the 4T1 model receiving PBS control or ITPP treatment. Arrows indicate days when mice received treatment. Values show the average tumor %sO2 and error bars represent standard deviation. *p < 0.0332, n = 4–5, field of view 25 × 25 mm.

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