Fig. 7 | Scientific Reports

Fig. 7

From: Potentiation of immune checkpoint blockade with an ITPP radiosensitizer studied with oxygen saturation measurements from photoacoustic imaging

Fig. 7

%sO2 after the first ITPP treatment positively correlated with combination ITPP and ICB tumor control. (a,b) The study timelines. PAI was performed 3 h after administering ITPP. ICB was administered immediately after PAI on the initial treatment day. ICB was administered 3 h after ITPP on days without PAI. The comparison between the change in %sO2 (Δ%sO2) three hours after initial ITPP treatment relative to pretreatment, compared to the mass of c) CT26 and (d) 4T1 tumors after two combination ITPP, αCTLA-4 and αPD-1 treatments. A similar comparison between %sO2 three hours after initial ITPP treatment and the mass of (e) CT26 and f) 4T1 tumors after two combination treatments. Dotted lines represent the 95% confidence interval while the solid lines represent the linear best fit line. n = 10–13.

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