Table 15 Solubility of mesalazine in different media.
Dissolution medium | Water | 0.1 N Hydrochloric acid (pH 1.2) | pH 4.5 | pH 5.5 | pH 6.0 | pH 6.8 | |
|---|---|---|---|---|---|---|---|
37 °C Maximum solubility (mg/ml) | 1.0 | 11.4 | 1.0 | 1.6 | 1.8 | 5.1 |
Dissolution medium | Water | 0.1 N Hydrochloric acid (pH 1.2) | pH 4.5 | pH 5.5 | pH 6.0 | pH 6.8 | |
|---|---|---|---|---|---|---|---|
37 °C Maximum solubility (mg/ml) | 1.0 | 11.4 | 1.0 | 1.6 | 1.8 | 5.1 |
