Table 18 Dissolution of tablets with different film thicknesses.
Batch no.\Film thickness (mm)\Dissolution (%) | |||||
|---|---|---|---|---|---|
Medium | Sampling time (h) | 20210525-3 | 21082303-3 | 20220927-1 | L20084A |
1.6 mm | 1.8 mm | 1.5 mm | NA | ||
0.1 N HCl | 2 | 0 | 0 | 0 | 0 |
pH 4.5 | 3 | 0 | 0 | 0 | 0 |
pH 5.5 | 4 | 1 | 0.1 | 0.3 | 0.1 |
pH 6.0 | 5 | 11.5 | 5 | 0.3 | 0.1 |
pH 6.8 | 5.08 | 15 | 6.8 | 0.3 | 0.1 |
pH 6.8 | 5.16 | 19.2 | 9.7 | 0.3 | 0.1 |
pH 6.8 | 5.25 | 25.7 | 14.1 | 1.0 | 0.6 |
pH 6.8 | 5.5 | 68.4 | 48.2 | 72 | 67.3 |
pH 6.8 | 5.75 | 99.1 | 93.7 | 101.7 | 99.7 |
pH 6.8 | 6 | 99.1 | 95.6 | 101.9 | 100.2 |
pH 6.8 | 6.5 | 99.9 | 102.8 | 102 | 100.4 |
