Table 7 Dissolution of the homemade formulation with different number of reciprocations (reciprocating frequencies).
Medium | Time (h) | 21082305-2 (Dip 10, %) | 21082305-2 (Dip 15, %) | 21091801-2 (Dip 10, %) | 21091801-2 (Dip 15, %) | 20220927-1 (Dip 10, %) | 20220927-1 (Dip 15, %) | L20084A (Dip 10, %) | L20084A (Dip 15, %) |
|---|---|---|---|---|---|---|---|---|---|
0.1 N Hydrochloric acid | 2 | 0.1 | 0.1 | 0.1 | 0.1 | 0 | 0 | 0 | 0 |
pH 4.5 | 3 | 0.1 | 0.1 | 0.1 | 0.1 | 0 | 0 | 0 | 0 |
pH 5.5 | 4 | 0.1 | 0.1 | 0.1 | 0.1 | 0.3 | 0.3 | 0.1 | 0.1 |
pH 6.0 | 5 | 0.1 | 0.1 | 0.1 | 0.1 | 0.3 | 0.3 | 0.1 | 0.1 |
pH 6.8 (5 min) | 5.08 | 0.2 | 0.2 | 0.2 | 0.2 | 0.3 | 0.3 | 0.1 | 0.1 |
pH 6.8 (10 min) | 5.16 | 0.1 | 0.1 | 0.2 | 0.2 | 0.3 | 0.3 | 0.1 | 0.1 |
pH 6.8 (15 min) | 5.25 | 0.2 | 0.3 | 1.2 | 1.6 | 1 | 1 | 0.5 | 0.6 |
pH 6.8 (30 min) | 5.5 | 66 | 69 | 63 | 66 | 69 | 72 | 64 | 67.3 |
pH 6.8 (45 min) | 5.75 | 94.7 | 96.9 | 94.1 | 95.4 | 98.6 | 101.7 | 96.5 | 99.7 |
pH 6.8 (60 min) | 6 | 95 | 97.1 | 94.6 | 96.1 | 99.4 | 101.9 | 98.8 | 100.2 |
pH 6.8 (90 min) | 6.5 | 98.1 | 98.9 | 98.1 | 98.5 | 101.1 | 102 | 99.8 | 100.4 |
Similarity factor (f2) | 86 | 88 | 83 | 82 | |||||
