Table 1 Mediation effect of gut Microbiome on CKD via immune cell.
Exposure database | Exposure | Mediator | Outcome | Direct effect β1 | Direct effect β2 | Total effect β_total | Mediate effect(95%CI) | P-val | Mediation Proportion |
|---|---|---|---|---|---|---|---|---|---|
MiBioGen | Genus Coprococcus3.id.11,303 | CD3 on CD28 + CD4-CD8- T cell | CKD | -0.3545 | -0.0282 | -0.1364 | 0.0100 (-0.03,0.023) | 0.1290 | -7.33% |
MiBioGen | Naive-mature B cell Absolute Count | CKD | 0.3063 | -0.0295 | -0.1364 | `- 0.0090 (-0.021,0.003) | 0.1331 | 6.62% | |
MiBioGen | Genus.Lachnospiraceae | Naive-mature B cell Absolute Count | CKD | 0.2721 | -0.0295 | -0.1183 | `- 0.0080 (-0.018,0.001) | 0.0982 | 6.78% |
MiBioGen | Order.Desulfovibrionales | CD45RA + CD8 + T cell %T cell | CKD | 0.2192 | 0.0044 | 0.1420 | 0.0009 (0, 0.002) | 0.1423 | 0.67% |
DMP | Species Alistipes_indistinctus | CD28 + CD45RA + CD8 + T cell % | CKD | -0.2395 | 0.0048 | 0.0729 | ´-0.0012 (-0.002,0.000) | 0.0033 | -1.59% |
DMP | CD28 + CD45RA + CD8dim T cell %T cell | CKD | -0.2028 | 0.0110 | 0.0729 | `-0.0022 (-0.005,0.000) | 0.0560 | -3.06% | |
DMP | CD45RA + CD8 + T cell % | CKD | -0.2498 | 0.0044 | 0.0729 | ´-0.0011 (-0.002,0.000) | 0.0832 | -1.50% | |
DMP | CD86 on myeloid Dendritic Cell | CKD | -0.1896 | -0.0450 | 0.0729 | 0.0085 (-0.002,0.019) | 0.1032 | 11.72% | |
DMP | Species_ Alistipes_putredinis | CD28 + CD45RA + CD8 + T cell % | CKD | -0.3274 | 0.0048 | 0.1310 | ´-0.00159 (-0.003,0.000) | 0.0094 | -1.21% |
DMP | CD45RA + CD8 + T cell % | CKD | -0.4103 | 0.0044 | 0.1310 | ´-0.0018 (-0.004,0.000) | 0.0685 | -1.37% | |
DMP | Species_ Lachnospiraceae_bacterium | CD86 on myeloid Dendritic Cell | CKD | -0.1289 | -0.0450 | 0.0404 | 0.0058 (0.000,0.012) | 0.0613 | 14.36% |
DMP | Genus_Coprobacter | CD33 on Granulocytic Myeloid-Derived Suppressor Cells | CKD | -0.5003 | 0.0243 | 0.0820 | `-0.012 (-0.024,-0.001) | 0.0401 | -14.81% |
DMP | Species_Coprobacter_fastidiosus | CKD | -0.4992 | 0.0243 | 0.0818 | ´-0.0121 (-0.024,-0.001) | 0.0401 | -14.83% | |
DMP | Genus_Streptococcus | CKD | 0.2985 | 0.0243 | -0.0678 | 0.0072 (-0.001,0.016) | 0.0897 | -10.70% | |
DMP | 1.4.dihydroxy.2.naphthoate. biosynthesis.II.plants | CKD | 0.2602 | 0.0243 | 0.0634 | 0.0063 (-0.001,0.013) | 0.0839 | 9.97% | |
DMP | Naive-mature B cell Absolute Count | CKD | 0.1390 | -0.0295 | 0.0634 | `-0.0041 (-0.009,0.001) | 0.1166 | -6.47% | |
DMP | Starch.degradation.III | CD45RA + CD8 + T cell % | CKD | 0.0771 | 0.0044 | -0.0408 | 0.0003 (0.000,0.001) | 0.1436 | -0.83% |
DMP | Sucrose.degradation.IV. .sucrose.phosphorylase | HVEM on CD4 + T cell | CKD | 0.4229 | -0.0215 | 0.1167 | ´-0.009 (-0.020,0.002) | 0.1072 | -7.78% |
DMP | CD45RA on Terminally Differentiated CD8 + T cell | CKD | 0.2939 | -0.0605 | 0.1167 | ´-0.0178 (-0.037,0.001) | 0.0687 | -15.24% | |
DMP | Purine.nucleotides.de.novo | IgD on IgD + CD24- B cell | CKD | 0.1977 | -0.0349 | -0.0947 | ´-0.0070 (-0.016,0.002) | 0.1280 | 7.29% |
DMP | Polyamine.biosynthesis.I | CD45RA + CD8 + T cell % | CKD | 0.3595 | 0.0044 | -0.1265 | 0.0016 (0.000,0.003) | 0.0747 | -1.25% |
DMP | CD28 + CD45RA + CD8 + T cell %T cell | CKD | 0.2548 | 0.0048 | -0.1265 | 0.0012 (0.000,0.002) | 0.0221 | -0.98% |
