Table 1 Clinical characteristics of participants.

From: Serum untargeted metabolomics alterations in systemic lupus erythematosus patients with elevated serum ferritin

Characteristic

F1 N = 32

F2 N = 20

P

Ferritin (ng/ml)

82.45 [19.60, 182.55]

742.35 [489.05, 1143.17]

 < 0.001

Age (years)

38.69 ± 14.24

46.75 ± 13.87

0.05

Gender (%)

 Male

2 (6.25)

4 (20.00)

0.189

 Female

30 (93.75)

16 (80.00)

 

SLEDAI

8.00 [3.75, 12.00]

8.50 [4.75, 12.25]

0.631

CRP (mg/L)

3.30 [2.00, 12.45]

5.85 [3.08, 22.60]

0.122

ESR (mm/h)

30.00 [13.00, 77.00]

52.50 [33.50, 83.75]

0.103

PCT (ng/ml)

0.05 [0.02, 0.12]

0.16 [0.04, 0.49]

0.101

Normal (%)

25 (100.00)

10 (71.43)

0.012

Increase (%)

0 (0.00)

4 (28.57)

 

IL-6 (pg/ml)

2.61 [1.32, 5.96]

9.12 [2.06, 37.92]

0.085

 Normal (%)

17 (73.91)

6 (42.86)

0.124

 Increase (%)

6 (26.09)

8 (57.14)

 

WBC (10^9/L)

5.35 [3.42, 6.43]

3.85 [2.88, 6.80]

0.333

HB (g/L)

96.56 ± 29.75

96.00 ± 19.79

0.941

PLT (10^9/L)

184.50 [140.00, 250.25]

193.00 [109.50, 227.75]

0.492

BUN (mmol/L)

6.05 [5.23, 8.15]

6.75 [5.25, 9.83]

0.408

SCr (umol/l)

60.50 [44.00, 97.28]

58.00 [46.50, 91.00]

0.97

Urinary total protein/Creatinine (g/g)

0.33 [0.09, 1.38]

0.75 [0.32, 2.37]

0.053

24 h Urinary protein (mg)

583.00 [328.00, 3218.00]

610.00 [302.50, 1793.00]

0.882

Albumin (g/L)

35.29 ± 5.20

31.02 ± 3.86

0.003

ALT (U/L)

15.05 [8.55, 19.23]

25.35 [19.08, 34.75]

0.001

AST (U/L)

16.50 [12.63, 20.97]

23.40 [20.00, 33.47]

0.002

Cholesterol (mmol/l)

4.53 [3.70, 5.03]

4.56 [4.11, 5.26]

0.543

LDL (mmol/l)

2.30 [1.81, 2.99]

2.54 [1.74, 3.13]

0.714

HDL (mmol/l)

1.37 ± 0.45

1.25 ± 0.61

0.447

IgA (g/L)

1.83 [1.36, 2.57]

2.38 [1.52, 3.54]

0.237

IgG (g/L)

10.50 [7.90, 13.35]

15.15 [10.72, 17.22]

0.054

IgM (g/L)

0.79 [0.55, 1.20]

1.00 [0.43, 1.39]

0.561

IgE (IU/ml)

25.00 [11.50, 107.50]

35.00 [15.25, 143.50]

0.5

C3 (g/L)

0.81 ± 0.27

0.73 ± 0.28

0.312

C4 (g/L)

0.18 [0.07, 0.26]

0.13 [0.04, 0.18]

0.474

Total Lymphocyte (10^9/l)

1.10 [0.60, 1.70]

0.65 [0.50, 1.08]

0.053

B Lymphocyte (10^9/l)

0.13 [0.04, 0.18]

0.05 [0.02, 0.10]

0.123

CD3+T cell (10^9/l)

0.90 [0.48, 1.41]

0.55 [0.39, 0.88]

0.096

CD3+CD4+T cell (10^9/l)

0.38 [0.26, 0.60]

0.20 [0.16, 0.34]

0.01

CD3+CD8+ T cell (10^9/l)

0.39 [0.21, 0.66]

0.29 [0.22, 0.51]

0.654

NK cell (10^9/l)

0.07 [0.05, 0.11]

0.04 [0.03, 0.08]

0.068

Anti-dsDNA antibody (IU/l)

170.65 [8.88, 405.52]

81.89 [10.00, 691.03]

0.805

 Positive (%)

16 (59.26)

6 (46.15)

0.659

 Negative (%)

11 (40.74)

7 (53.85)

 

LN (%)

 No

13 (40.62)

11 (55.00)

0.468

 Yes

19 (59.38)

9 (45.00)

 

Hematologic involvement (%)

 No

9 (47.37)

1 (7.69)

0.024

 Yes

10 (52.63)

12 (92.31)

 

Serositis (%)

 No

3 (23.08)

1 (9.09)

0.596

 Yes

10 (76.92)

10 (90.91)

 
  1. Values were presented as mean ± SD, median (interquartile range), or number (percentage). SLEDAI systemic lupus erythematosus disease activity index, WBC white blood cell, HB hemoglobin, PLT platelet, ALT alanine transaminase, AST aspartate transaminase, BUN blood urea nitrogen, SCr serum creatinine, LDL low-density lipoprotein, HDL high density lipoprotein, CRP C-reactive protein, ESR erythrocyte sedimentation rate, IgA immunoglobulin A, IgM immunoglobulin M, IgG immunoglobulin G, IgE immunoglobulin E, C3 completement 3, C4 completement 4, PCT procalcitonin, IL-6 interleukin-6. LN, hospitalization diagnosed lupus nephritis; Hematologic involvement, leukopenia or autoimmune hemolytic anemia (AIHA) or thrombocytopenia; Serositis, pleural effusion or pericardial effusion.
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