Fig. 1 | Scientific Reports

Fig. 1

From: Temporal changes of hepatic drug-metabolizing enzymes mediated by hepatic ischemia-reperfusion injury and the protective effect of Oridonin

Fig. 1

Alterations and correlations in hepatic injury indicators and CYPs/UGTs with different durations of hepatic ischemia-reperfusion. (A) Serum levels of ALT, AST, and LDH during different time periods of hepatic IR (n = 6). (B) The levels of GSH, MDA, SOD, and MPO in hepatic tissue during different time periods of hepatic IR (n = 6). (C) The levels of serum inflammatory factors TNF-α and IL-1β during different time periods of hepatic IR (n = 6). (D) The mRNA levels of CYPs/UGTs during different time periods of hepatic IR (n = 6). (E) The concentration of metabolite 6β-hydroxytestosterone in the enzymatic experiment of testosterone (n = 6). (F) The correlation between CYPs/UGTs and hepatic injury indicators. (*p < 0.05, **p < 0.01, ***p < 0.001, ns: no significance, vs. 0 h; #p < 0.05, ##p < 0.01, vs. 6 h).

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