Fig. 10 | Scientific Reports

Fig. 10

From: Vincamine induces cytoprotective autophagy via regulation of ampk/mtor signaling pathway in gentamicin-induced hepatotoxicity and nephrotoxicity in rats

Fig. 10

Photomicrographs of rat renal tissue of: (a,b) control group and VIN group showing normal kidney structure. The renal cortex is formed of renal glomerulus (g) (surrounding by Bowman’s space (s), proximal (PCT) & distal (DCT) convoluted tubules with vesicular nuclei. (c) GET group displays a distorted, shrunken renal glomerulus (g) with dilated Bowman’s space (s), darkly stained cells (arrows) of proximal (PCT) & distal (DCT) convoluted tubules, intra luminal hyaline, and inflammatory cell infiltration. (d) GET/VIN group reveals kidney tissue nearly approach normal structure except for glomerular congested blood capillaries. (H&E X 400, scale bar = 50 μm). (e) Analysis of Semi-quantitative scoring. Data are presented as mean ± SD, (n = 6). Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. Where ###; p < 0.001, compared to the control group, ***; p < 0.001, compared to the GET group. The analysis was performed per high-power field (HPF).

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