Fig. 4 | Scientific Reports

Fig. 4

From: Dominant and cross-reactive S1-specific memory B cell response induced by primary SARS-CoV-2 infection

Fig. 4

Epitope mapping and neutralizing activities of hmAbs derived from SARS-CoV-2 S1-specific MBCs. (A) The six distinct epitope groups of S1-directed hmAbs identified by epitope binning using BLI. The percentage of residual binding was calculated as the binding value of the second antibody in the presence of the first antibody divided by the binding value of the second antibody alone. Percentage of residual binding < 20% is highlighted in dark purple; 20–80% is highlighted in purple. (B) The scheme of five epitope groups of RBD-directed mAbs showing epitope overlap among them. (C and D) Neutralizing activities of S1-directed hmAbs tested on SARS-CoV-2 S-pseudotyped HIV-1. REGN10933, a commercial SARS-CoV-2 specific hmAb; 872, an S2-hmAb.

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