Fig. 5 | Scientific Reports

Fig. 5

From: Dominant and cross-reactive S1-specific memory B cell response induced by primary SARS-CoV-2 infection

Fig. 5

Neutralization of hmAbs with diverse epitopes on authentic virus and their protection in mouse model. (A) Neutralizing activities of hmAbs against wildtype SARS-CoV-2 were measured by FRNT. (B) Experimental design of hmAbs to protect mice from SARS-CoV-2 wildtype virus infection by prophylactic application. TheAd5-ACE2 transduced BALB/c mice were injected intraperitoneally with hmAbs one day before the SARS-CoV-2 challenge. Three days after the challenge, virus titers in lung tissues were detected by FRNT. (C) The virus titers in lung tissues after hmAbs administration are shown. For each hmAb, 20 µg, 50 µg,100 µg, and 200 µg were used per mouse (n = 3 mice per dose group). Groups treated with PBS or mock antibody (4B8, a Zika virus NS1-hmAb) were used as controls. FFU/gm, focus forming unit/gram. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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