Table 2 Baseline data for training and validation sets.

From: Preoperative prediction of major adverse outcomes after total arch replacement in acute type A aortic dissection based on machine learning ensemble

 

Training set (N = 508)

Validation set (N = 127)

P value

Non-MAO

380 (74.8%)

95 (74.8%)

1.00

MAO

128 (25.2%)

32 (25.2%)

1.00

Demographics

Age (year)

47.47 ± 9.85

48.86 ± 10.91

0.21

Male (%)

89 (17.52%)

18 (14.17%)

0.18

Height (cm)

171.43 ± 7.89

170.44 ± 7.23

0.19

Weight (kg)

75.5 ± 13.68

74.62 ± 13.41

0.67

Medical history

Current smoking

182 (35.83%)

41 (32.28%)

0.52

Current alcohol drinking

144 (28.35%)

36 (28.35%)

1.00

Allergy history

57 (11.22%)

10 (7.87%)

0.35

Hypertension

412 (81.1%)

111 (87.4%)

0.12

Diabetes

25 (4.92%)

10 (7.87%)

0.28

Stroke

19 (3.74%)

3 (2.36%)

0.63

Chronic lung diseases

62 (12.2%)

12 (9.45%)

0.48

Chronic kidney disease

31 (6.1%)

3 (2.36%)

0.15

Chronic liver disease

25 (4.92%)

3 (2.36%)

0.31

Gastrointestinal bleeding

3 (0.59%)

0 (0%)

0.88

Marfan syndrome

9 (1.77%)

1 (0.79%)

0.69

Coronary heart disease

33 (6.5%)

12 (9.45%)

0.33

Prior sternotomy

cardiovascular surgery

46 (9.06%)

10 (7.87%)

0.81

Prior interventional

cardiovascular surgery

24 (4.72%)

6 (4.72%)

1.00

Symptom

Mechanical ventilation at referral

7 (1.38%)

2 (1.57%)

1.00

Resuscitation before surgery

4 (0.79%)

1 (0.79%)

1.00

Altered mental status

14 (2.76%)

5 (3.94%)

0.68

Abnormal defecation

15 (2.95%)

1 (0.79%)

0.28

Abnormal urination

24 (4.72%)

5 (3.94%)

0.89

Chest pain

481 (94.69%)

122 (96.06%)

0.68

Back pain

252 (49.61%)

64 (50.39%)

0.95

Abdominal pain

71 (13.98%)

12 (9.45%)

0.23

Head or Neck pain

35 (6.89%)

8 (6.3%)

0.97

Malperfusion

95 (18.7%)

24 (18.9%)

1.00

Laboratory results

CK-MB (ng/mL)

1.32 ± 1.15

1.22 ± 0.95

0.66

RBC (×1012/L)

3.95 ± 0.76

3.95 ± 0.74

0.96

Hemoglobin (g/L)

120.39 ± 23.03

119.35 ± 23.24

0.91

WBC (×109/L)

10.08 ± 3.88

10.03 ± 3.94

0.87

Neutrophil (%)

79.29 ± 10.66

77.82 ± 14.78

0.89

Platelet (×109/L)

173.76 ± 69.84

170.43 ± 77.52

0.32

Alanine aminotransferase (U/L)

26.3 ± 11.23

25.1 ± 10.27

0.80

Aspartate aminotransferase (U/L)

23.7 ± 10.75

22.8 ± 10.59

0.64

Total bilirubin (µmol/L)

18.98 ± 13.68

17.73 ± 12.58

0.53

Direct bilirubin (µmol/L)

7.25 ± 5.3

6.53 ± 4.38

0.10

Creatinine (µmol/L)

89.1 ± 36.76

90.2 ± 35.23

0.79

Blood urea nitrogen (mmol/L)

6.88 ± 3.56

7.48 ± 4.16

0.24

Uric acid (µmol/L)

424.1 ± 280.09

384.63 ± 138.36

0.36

Albumin (g/L)

38.04 ± 4.63

37.3 ± 4.6

0.16

eGFR (mL/min/1.73m2)

97.56 ± 29.27

98.69 ± 29.42

0.27

D-dimer (mg/L)

2.34 (0.82–10.56)

2.53 (1.13–11.12)

0.34

APTT (sec)

29.25 ± 4.28

29.35 ± 4.77

0.91

INR

1.18 ± 0.34

1.2 ± 0.36

0.37

Image results

Severe aortic regurgitation (%)

114 (22.44%)

34 (26.77%)

0.36

Large pericardial effusion (%)

19 (3.74%)

7 (5.51%)

0.52

Ejection fraction (%)

61.68 ± 7.02

61.66 ± 6.02

0.70

LVEDD (mm)

50.77 ± 8.99

49.69 ± 7.39

0.46

Ascending aorta diameter (mm)

45.27 ± 7.33

44.8 ± 8.02

0.36

Procedure type

Aortic root repair

42 (8.27%)

9 (7.09%)

0.80

Wheat

4 (0.79%)

3 (2.36%)

0.30

David

20 (3.94%)

7 (5.51%)

0.59

Bentall

110 (21.65%)

32 (25.2%)

0.46

CABG

52 (10.24%)

17 (13.39%)

0.39

Septal defect repair

8 (1.57%)

1 (0.79%)

0.80

Mitral Tricuspid valve replacement

3 (0.59%)

3 (2.36%)

0.18

Valvuloplasty

18 (3.54%)

3 (2.36%)

0.70

  1. Values are expressed as the means ± standard deviations, numbers, or medians (interquartile range, IQR). A P value for a linear trend of < 0.05 is statistically significant. CK-MB, creatine kinase MB isoenzyme; RBC, red blood cell; WBC, white blood cell; eGFR, estimated glomerular filtration rate; APTT, activated partial thromboplastin time; INR, International Normalized Ratio; LVEDD, left ventricular end diastolic diameter; CABG, coronary artery bypass graft.