Fig. 6 | Scientific Reports

Fig. 6

From: Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line stimulated with live probiotic bacteria

Fig. 6

B. longum regulates inflammatory response differently in MHCO and Caco-2. (A) Enrichment plot of genes in Nf-Kappa B Signaling Pathway (KEGG) for MHCO (left panel) and Caco-2 (right panel). (B) Heatmap of relative expression of inflammatory response-related genes by co-cultivation of B. longum in Caco-2 and MHCO. Statistical significance was evaluated by a Deseq2 (*adjusted p-value < 0.05, ** adjusted p-value < 0.01, *** adjusted p-value < 0.001). (C) TPM values of representative chemokine, NF-κB related, and inflammatory cytokine genes. Filled and unfilled circles indicate two independent experiments (each three replicates). Data are presented as the mean ± Standard derivatives (SD). Statistical significance was evaluated by Deseq2.

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