Table 2 Cox regression analysis for 30d mortality of septic patients (n = 204).

From: Impact of glucocorticoid receptor polymorphism rs6198 on sepsis survival in a prospective multicenter cohort

 

Variable

Univariate

Multivariate

HR

p-value

HR

p-value

Base characteristics

rs6198 Genotype TT*

2.44 (1.27–4.69)

0.008

3.56 (1.22–10.38)

0.020

Age

1.02 (1.00–1.04)

0.031

1.01 (0.97–1.05)

0.654

SOFA Score, day 1

1.34 (1.25–1.45)

 < 0.001

1.13 (0.99–1.29)

0.072

SAPS2, day 1

1.09 (1.05–1.14)

 < 0.001

1.06 (1.99–1.12)

0.066

Hydrocortisone therapy**

2.05 (1.22–3.47)

0.007

2.16 (0.88–5.28)

0.092

Lab values

Serum lactate (mg/dL)

1.31 (1.22–1.41)

 < 0.001

1.15 (1.01–1.31)

0.035

Bilirubin (mg/dL)

1.31 (0.96–1.80)

0.090

1.61 (0.96–2.68)

0.069

  1. Multivariate cox regression with Hazard ratios and 95% CI Intervals, *Genotype of rs6198-SNP in NR3C1-Gene ** during ICU stay, as described in methods.
  2. Significant values are in bold.
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