Table 2 Summary of missense mutations identified in efflux-related antimicrobial resistance (AMR) genes in E. coli and K. pneumoniae. For each variant, the gene, amino acid change, and a brief annotation are reported.
Strain | Gene | Amino acid change | Mutation type | Annotation/comment |
|---|---|---|---|---|
E. coli | acrB | p.His596Asn | Missense | Transmembrane domain (predicted) |
E. coli | acrB | p.Ser1043Asn | Missense | Periplasmic region (unknown role) |
E. coli | acrA | p.Thr104Ala | Missense | Helical region (unknown role) |
E. coli | marR | p.Gly103Ser | Missense | Quinolone resistance in animals9 |
E. coli | marR | p.Tyr137His | Missense | Carbapenem resistance10 |
E. coli | marA | p.Ser127Asn | Missense | C-terminal (DNA-binding domain) |
K. pneumoniae | acrA | p.Val313Ile | Missense | Conservative change |
K. pneumoniae | acrA | p.Ala188Thr | Missense | Reported in tigecycline-resistant strain11 |
