Table 3 Differentially abundant metabolite information. Metabolites exhibiting upregulated expression were observed in the mutant strain ARTP-9 (M4) compared to the T. reesei CICC 2626 (O4).

From: Multi-omics analysis of Trichoderma reesei mutant with high glucanase activity

Metabolite

Molecular formula

log2FC

P value

VIP

Upregulated expression

beta-Alanyl-L-lysine

C9H19N3O3

6.17

0.04

1.42

2-Heptanone

C7H14O

2.64

0.02

2.10

Linatine

C10H17N3O5

2.39

0.00

2.34

Gentamicin C1a

C19H39N5O7

1.76

0.00

1.80

2,4-Dihydroxypteridine

C6H4N4O2

1.53

0.04

1.65

3-Methylthiopropionic acid

C4H8O2S

1.11

0.03

1.79

Terephthalate

C8H6O4

0.90

0.03

1.66

Taurine

C2H7NO3S

0.88

0.04

1.40

N7-Methylguanosine

C11H16N5O5

0.84

0.04

1.38

Pyridoxal phosphate

C8H10NO6P

0.83

0.04

1.11

Palmitoleic acid

C16H30O2

0.76

0.00

2.28

Downregulated expression

Beta-Carboline

C11H8N2

 − 1.86

0.00

1.95

N-Acetyl-beta-glucosaminylamine

C8H16N2O5

 − 1.60

0.04

1.69

L-Histidinol

C6H11N3O

 − 1.45

0.02

1.57

CMP

C9H14N3O8P

 − 1.17

0.00

2.28

Spermine

C10H26N4

 − 0.88

0.04

1.58

Niacinamide

C6H6N2O

 − 0.86

0.02

1.73

Glutathione

C10H17N3O6S

 − 0.86

0.02

1.51

(R)-Pantolactone

C6H10O3

 − 0.83

0.00

2.45

Stearidonic acid

C18H28O2

 − 0.69

0.04

1.59

S-Adenosylhomocysteine

C14H20N6O5S

 − 0.65

0.01

1.58

Nonadecanoic acid

C19H38O2

 − 0.63

0.00

1.18

Isophorone

C9H14O

 − 0.59

0.03

1.81

  1. Conversely, other metabolites showed downregulated expression in M4 relative to O4. A log2 fold change (log2FC) ≥ 1 was used to define upregulated metabolites, while a log2FC ≤  − 1 indicated downregulated metabolites. Variable importance in projection (VIP) refers to the relative influence of each metabolite in the group; metabolites with higher VIP values are more influential.
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