Table 1 The heterogeneity and pleiotropic analyses for causality between immunophenotypes and HIV.

From: Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian randomization analysis

 

Heterogeneity test

Pleiotropic test

Exposures

Methods

Q

Q_dif

Pval

Methods

SE

Pval

IgD + %B cell

MR.Egger

0.643929637

3

0.886306075

Egger_Intercept

0.011695481

0.496969894

IVW

1.238052584

4

0.871794648

IgD + CD38br AC

MR.Egger

9.390441725

12

0.669269114

Egger_Intercept

0.0092191

0.512747224

IVW

9.845461276

13

0.706520088

CD62L- plasmacytoid DC %DC

MR.Egger

11.57713736

9

0.238211098

Egger_Intercept

0.01250454

0.804180118

IVW

11.6610229

10

0.308383311

Basophil %CD33dim HLA DR- CD66b-

MR.Egger

12.06593318

11

0.358707702

Egger_Intercept

0.008125787

0.834090958

IVW

12.1163963

12

0.436377586

CM CD8br %T cell

MR.Egger

8.024716603

8

0.431059456

Egger_Intercept

0.025086421

0.336278587

IVW

9.074318188

9

0.430442463

Naive DN (CD4-CD8-) %DN

MR.Egger

11.35721505

9

0.252015958

Egger_Intercept

0.018942989

0.301536002

IVW

12.87306123

10

0.230855978

TD DN (CD4-CD8-) AC

MR.Egger

8.775265155

12

0.721996475

Egger_Intercept

0.011563367

0.827104745

IVW

8.825100651

13

0.786020845

Transitional AC

MR.Egger

11.47175848

13

0.571360176

Egger_Intercept

0.008545089

0.240825991

IVW

12.98239262

14

0.527910521

CD4 + AC

MR.Egger

6.590300845

9

0.679689528

Egger_Intercept

0.022400606

0.233738423

IVW

8.219700192

10

0.607386512

Lymphocyte AC

MR.Egger

2.228950146

6

0.897484028

Egger_Intercept

0.008123094

0.612198343

IVW

2.514662468

7

0.925988925

CD3- lymphocyte %leukocyte

MR.Egger

7.943596037

7

0.337593844

Egger_Intercept

0.007698984

0.392015129

IVW

8.887789637

8

0.351850222

CD28 + CD45RA + CD8br %T cell

MR.Egger

8.367066768

10

0.593029744

Egger_Intercept

0.004690224

0.593690482

IVW

8.670732841

11

0.652255623

CD19 on IgD + CD24-

MR.Egger

12.8578492

10

0.231728605

Egger_Intercept

0.014583887

0.758580726

IVW

12.98615281

11

0.29423142

CD24 on memory B cell

MR.Egger

5.581227014

11

0.899795627

Egger_Intercept

0.005767217

0.068767389

IVW

9.649589448

12

0.646671474

CD25 on CD24 + CD27 + 

MR.Egger

8.840961748

14

0.841101597

Egger_Intercept

0.008413337

0.953104271

IVW

8.84454634

15

0.885504276

CD25 on memory B cell

MR.Egger

10.30211171

11

0.503434238

Egger_Intercept

0.00834607

0.376833363

IVW

11.15025648

12

0.516087507

CD3 on secreting Treg

MR.Egger

4.056637667

6

0.66901185

Egger_Intercept

0.00828587

0.663667495

IVW

4.265597427

7

0.748727904

CD3 on CD28 + CD45RA- CD8br

MR.Egger

6.612784709

7

0.470277511

Egger_Intercept

0.011963019

0.372685924

IVW

7.519561176

8

0.481747727

CD3 on CD4 + 

MR.Egger

12.73657245

10

0.238775559

Egger_Intercept

0.015319083

0.557511395

IVW

13.20553327

11

0.280104449

CD33 on CD66b +  + myeloid cell

MR.Egger

5.258262284

5

0.385181347

Egger_Intercept

0.010236541

0.134463916

IVW

8.606097233

6

0.19697258

CD33 on Mo MDSC

MR.Egger

5.002129974

8

0.757348454

Egger_Intercept

0.00622216

0.176424425

IVW

7.200705271

9

0.616231896

CCR2 on granulocyte

MR.Egger

2.926201174

5

0.711362421

Egger_Intercept

0.015755406

0.939958319

IVW

2.932471155

6

0.817273472

CD14 on Mo MDSC

MR.Egger

7.275235473

12

0.838901726

Egger_Intercept

0.010545632

0.985732624

IVW

7.27556885

13

0.887397329

SSC-A on HLA DR + CD4 + 

MR.Egger

6.896473534

7

0.439738113

Egger_Intercept

0.015119111

0.992350678

IVW

6.89657223

8

0.547831861

HLA DR on CD33dim HLA DR + CD11b + 

MR.Egger

2.460324162

6

0.87288133

Egger_Intercept

0.011624914

0.826879922

IVW

2.512515685

7

0.926151676

CD3- lymphocyte %lymphocyte

MR.Egger

NA

NA

NA

Egger_Intercept

NA

NA

IVW

NA

NA

NA

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