Fig. 2

Construction of a prognostic model based on DEGs among PMG-related subtypes. (A) Screening process of PMGs, excluding 5308 genes associated only with prognosis and 877 mitochondrial genes without significant prognostic value; (B) GO enrichment analysis of PMGs; (C) Consensus matrix heatmap based on PMGs in the TCGA-LUAD cohort; (D) Cumulative distribution function (CDF) curve based on PMGs in the TCGA-LUAD cohort; (E) PCA visualization of LUAD molecular subtypes based on PMGs, with ellipses representing the distribution ranges of different subtypes in low-dimensional space; (F) Kaplan–Meier survival analysis of the identified subtypes; (G) Heatmap of GSVA scores for PMG-associated subtypes based on Hallmark gene sets, with each square representing a single sample; (H) Boxplots illustrating the GSVA score distributions of six key mitochondrial-related pathways between C1 and C2 subtypes; (I) Violin plots showing the comparison of ESTIMATE scores between PMG-associated subtypes; (J) Violin plots depicting the comparison of tumor purity between PMG-associated subtypes; (K) Boxplots illustrating differences in immune cell infiltration levels between PMG-associated subtypes.