Fig. 1 | Scientific Reports

Fig. 1

From: Study of caspase-6 activity in aggressive HCT116 cells using methotrexate-encapsulated lactoferrin-conjugated solid lipid nanoparticles via in silico and in vitro approaches

Fig. 1

(a) MTX-LF-SLNs infiltrate colon cancer cells through endocytosis, discharging methotrexate while reusing lactoferrin for ongoing targeting. (b) Gradual development of MTX-SLNs through emulsification, sonication, stirring and lyophilization with trehalose to ensure stability. (c) The conjugation of lactoferrin through carbodiimide coupling improves targeting by creating robust covalent links with glyceryl monostearate.

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