Table 1 HIV-1 Inhibition concentration (IC50) on TZM-Bl cells for Penicillium Rubens P03MB2 extracts obtained from MEA media.

From: Combining an OSMAC approach and untargeted metabolomics to profile compounds exhibiting anti-HIV-1 activities in an endophytic fungus, Penicillium Rubens P03MB2

Penicillium rubens P03MB2 fractions (MEA media)

IC50 (µg/mL)

HIV inhibition %

MEA MAX crude extracts

0,0008991

64,5

MEA MAX 5%

0,001445

65

MEA MAX 45%

1,21338

79,5

MEA MAX 95%

3,40401

87

MEA MCX crude extracts

1,2971

54

MEA MCX 5%

3.583e + 013

97,5

MEA MCX 45%

5.950e + 016

88

MEA MCX 95%

0,2810

36

AZT

0,002407

101

  1. *Eluted in 5%, 45%, and 95% methanol.
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