Fig. 2 | Scientific Reports

Fig. 2

From: The immunomodulatory p43 secreted protein of Trichuris whipworm parasites is a lipid carrier that binds signalling lipids and precursors

Fig. 2

Hydrophobic ligand binding by Trichuris muris p43 and its orthologue from Trichuris trichiura p47. (A) T. muris p43 binds retinol in a binding site also occupied by oleic acid. (B) composite tryptophan intrinsic fluorescence spectrum of T. muris p43’s seven tryptophans with affect of addition of oleic acid; data were Savitsky-Golay 25 point smoothed and arithmetically brought to same peak value. (C) p47 of T. trichiura, the whipworm parasite of humans, binds fatty acids. (D) subtraction spectrum of the spectra ((DAUDA + p47)—(DAUDA alone)) yielding peak fluorescence emission at 482 nm, essentially identical to that for T. muris’s p43. The small sharp peaks at shorter wavelengths in the retinol and DAUDA specra are from water Raman scatter. 

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