Table 1 Sample characteristics by cognitive status.

From: Association of CSF neurogenin-1 levels with cognitive decline and structural MRI features in older adults

Characteristic

Overall, N = 666

CU, N = 161

CI, N = 505

p-value

Age, years

73 (7)

74 (6)

73 (8)

0.015

Education, years

16 (3)

16 (3)

16 (3)

0.054

Gender

 Male

384 (58%)

88 (55%)

296 (59%)

0.4

 Female

282 (42%)

73 (45%)

209 (41%)

APOE4 status

 APOE4 noncarriers

343 (52%)

123 (76%)

220 (44%)

 < 0.001

 APOE4 carriers

323 (48%)

38 (24%)

285 (56%)

MMSE

27 (3)

29 (1)

27 (3)

 < 0.001

CDR-SB

1.73 (1.78)

0.02 (0.12)

2.27 (1.72)

 < 0.001

ADAS-Cog-13

17 (9)

10 (5)

20 (9)

 < 0.001

Missing, n

5

0

5

 

RAVLT total score

34 (12)

45 (10)

31 (11)

 < 0.001

Missing, n

2

0

2

 

aHV

4.49 (0.79)

4.93 (0.54)

4.34 (0.81)

 < 0.001

Missing, n

84

10

74

 

aVV

26 (13)

22 (11)

27 (13)

 < 0.001

Missing, n

32

10

22

 

Amyloid status

 Amyloid − 

232 (35%)

101 (63%)

131 (26%)

 < 0.001

 Amyloid + 

434 (65%)

60 (37%)

374 (74%)

CSF neurogenin-1 levels, RFU

52.3 (3.3)

52.1 (3.2)

52.4 (3.3)

0.4

  1. Continuous variables are summarized as Mean (SD) and categorical variables are summarized as n (%). Comparison of continuous variables was conducted using Welch Two Sample t-tests, and categorical variables were compared using Pearson’s chi-squared tests.
  2. CU cognitively unimpaired, CI cognitively impaired, APOE4 apolipoprotein E, MMSE mini-mental state examination, CDR-SB clinical dementia rating sum of boxes, ADAS-Cog-13 Alzheimer’s disease assessment scale cognitive subscale 13-item version, RAVLT Rey auditory verbal learning test, aHV adjusted hippocampal volume, aVV adjusted ventricular volume, RFU relative fluorescence units.
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