Table 2 Comparison between the NSIP pattern group and UIP pattern group in clinical baseline characteristics.

From: Prognostic significance of acute exacerbations and usual interstitial pneumonia in fibrotic interstitial lung disease

Characteristic

NSIP (n = 133)

UIP (n = 51)

P value

Age (year)

64.4 ± 13.5

70.0 ± 11.6

0.001

M/F

38/95

27/24

0.002

Smoking

26 (19.5%)

21 (41.2%)

0.003

Follow-up time, m

42.0 [22.5–64.0]

52.0 [35.0–74.0]

0.012

Pulmonary function tests1

   

FEV1% predicted

85.8 ± 21.7

78.3 ± 21.2

0.11

FVC% predicted

81.3 ± 17.9

70.9 ± 20.8

0.011

FEV1/FVC Ratio

86.3 ± 6.2

88.0 ± 8.9

0.27

DLCO% predicted

63.5 ± 19.8

52.0 ± 20.5

0.012

ILD-GAP Index1

   

Stage I (0,1)

62 (70.5%)

7 (24.1%)

<0.001

Stage II (2,3)

22 (25.0%)

16 (55.2%)

0.003

Stage III (4,5)

4 (4.5%)

3 (10.3%)

0.25

Stage IV (>5)

0 (0%)

3 (10.3%)

0.002

SPAP ≥ 37 mmHg

27 (20.3%)

19 (37.3%)

0.017

Outcome

   

Acute exacerbations of ILD

18 (13.5%)

14 (27.5%)

0.026

Combined with lung cancer

7 (5.3%)

3 (5.9%)

0.87

Death of all cause

19 (14.3%)

20 (39.2%)

<0.001

  1. Data are presented as the median [IQR] or mean ± SD or No. (%), and P < 0.05 was considered significant.
  2. 1PFTs (including FEV1, FVC, FEV1/FVC and DLCO) were performed in 88 NSIP pattern FILD patients and 29 UIP pattern FILD patients.
  3. UIP: usual interstitial pneumonia; NSIP: nonspecific interstitial pneumonia; M: male; F: female; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; ILD: interstitial lung disease; SPAP: systolic pulmonary artery pressure.
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