Table 2 Kinetic parameters of the interaction of N-terminal-truncated PRELP and chimeric PRELP with TGFβ1.

From: PRELP functions via multiple interactions with intrinsically weak affinity relying on ECM anchoring and remodeling

 

kon (× 105 M–1 s–1)

koff (s–1)

KD (× 10–6 M)

ΔNT24

2.77 ± 0.03

0.142 ± 0.008

0.512 ± 0.028

ΔNT50

0.751 ± 0.295

0.169 ± 0.113

1.55 ± 0.61

chPRELP

2.41 ± 0.49

0.362 ± 0.149

1.21 ± 0.37

  1. At least three independent measurements were carried out. The average values with standard errors are shown. kon, koff, and KD represent association rate constant, dissociation rate constant, and dissociation constant, respectively.
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