Fig. 7 | Scientific Reports

Fig. 7

From: Enhanced activity localization and microscale dosimetry in alpha-emitter radiopharmaceutical therapy using integrated autoradiography and histological imaging

Fig. 7

Aspects of near-cellular dosimetry. (A) iQID absolute activity quantification after calibration with activity in multiple orders of magnitude, showing a good correlation (high R2) between calibrated activity and measured activity. Line shown is identity (y = x). (B) Example of dosimetry for a tumor harvested at 3 days pi. Dosimetry based on anatomy-based volume reconstruction of 3 sections, spaced 28 μm apart. Dose rate map perfectly followed tissue outline, indicating a good spatial alignment. Dose rate was highly non-uniform, as is typical for (antibody-based) αRPT. (C) The corresponding cumulative dose-volume histogram, further illustrating the dose rate non-uniformity.

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