Table 2 Univariate and multivariate logistic regression of risk factors for synchronous bone metastasis.
Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
OR (95% CI) | P value | OR (95% CI) | P value | |
Age | 0.99 (0.98–0.99) | < 0.001 | 0.99 (0.98–0.99) | < 0.001 |
Race | ||||
White | Reference | – | Reference | – |
Black | 0.77 (0.67–0.87) | < 0.001 | 0.83 (0.72–0.95) | 0.007 |
Others | 0.69 (0.57–0.83) | < 0.001 | 0.73 (0.59–0.88) | 0.002 |
Sex | ||||
Male | Reference | – | Reference | – |
Female | 0.73 (0.68–0.79) | < 0.001 | 0.79 (0.73–0.85) | < 0.001 |
Primary site | ||||
Main bronchus | Reference | – | Reference | – |
Upper lobe of lung | 0.90 (0.80–1.00) | 0.059 | 0.97 (0.86–1.09) | 0.587 |
Middle lobe of lung | 0.79 (0.63–0.97) | 0.026 | 0.88 (0.70–1.11) | 0.288 |
Lower lobe of lung | 0.97 (0.85–1.10) | 0.602 | 1.02 (0.89–1.18) | 0.686 |
Overlapping lesion of lung | 1.06 (0.78–1.42) | 0.725 | 0.97 (0.70–1.33) | 0.848 |
Lung, NOS | 1.06 (0.92–1.22) | 0.395 | 1.03 (0.88–1.20) | 0.751 |
Laterality | ||||
Left | Reference | – | Reference | – |
Right | 0.93 (0.87–1.00) | 0.051 | 0.94 (0.87–1.01) | 0.103 |
Bilateral, single primary | 1.66 (1.17–2.31) | 0.003 | 0.79 (0.54–1.14) | 0.217 |
Paired site | 1.46 (1.10–1.91) | 0.007 | 1.07 (0.78–1.45) | 0.669 |
Others | 0.61 (0.30–1.11) | 0.128 | 0.53 (0.26–1.01) | 0.069 |
Histology type | ||||
LCNEC | Reference | – | Reference | – |
SCLC | 1.50 (1.27–1.78) | < 0.001 | 1.17 (0.98–1.40) | 0.083 |
T stage | ||||
T1 | Reference | – | Reference | – |
T2 | 1.52 (1.33–1.74) | < 0.001 | 1.29 (1.12–1.49) | < 0.001 |
T3 | 1.76 (1.53–2.02) | < 0.001 | 1.34 (1.16–1.56) | < 0.001 |
T4 | 1.83 (1.62–2.08) | < 0.001 | 1.33 (1.16–1.53) | < 0.001 |
N stage | ||||
N0 | Reference | – | Reference | – |
N1 | 1.43 (1.20–1.72) | < 0.001 | 1.24 (1.03–1.50) | 0.022 |
N2 | 2.03 (1.80–2.29) | < 0.001 | 1.60 (1.41–1.82) | < 0.001 |
N3 | 2.90 (2.55–3.30) | < 0.001 | 2.27 (1.98–2.60) | < 0.001 |
Marital status | ||||
Married | Reference | – | Reference | – |
Others | 0.81 (0.76–0.87) | < 0.001 | 0.87 (0.80–0.93) | < 0.001 |
Brain metastasis | ||||
No | Reference | – | Reference | – |
Yes | 1.47 (1.34–1.60) | < 0.001 | 1.39 (1.27–1.53) | < 0.001 |
Liver metastasis | ||||
No | Reference | – | Reference | – |
Yes | 4.25 (3.95–4.58) | < 0.001 | 3.87 (3.58–4.18) | < 0.001 |
Lung metastasis | ||||
No | Reference | – | Reference | – |
Yes | 2.03 (1.85–2.22) | < 0.001 | 1.48 (1.33–1.63) | < 0.001 |
