Fig. 7
Effect of M3F on Lipid Profile: TG (a), TC (b), Low Density Lipoprotein LDL (c), very low-density lipoprotein VLDL (d), high-density lipoprotein HDL (e), Coronary Risk Index (f), and Atherogenic Index (g) levels in PCM-treated mice. Each value represents mean ± S.E.M (n = 5), analyzed by One Way ANOVA using the LSD test for multiple comparisons. Level of significance is presented as *p < 0.05, **p < 0.01, ***p < 0.001 compared to PCM group and ###p < 0.001 compared to vehicle control group. Mice received a 7-day pretreatment with vehicle, silymarin, and M3F in respective groups. On day 8, hepatotoxicity was induced with PCM in all groups except vehicle control, and samples were collected 24 h post-PCM. Where HDL, high-density lipoprotein; LDL, Low Density Lipoprotein; M3F, test drug; PCM, Paracetamol; SIL, Silymarin; TC, Total Cholesterol; TG, triglyceride; VLDL, very low-density lipoprotein.
