Fig. 8
Effect of M3F on Antioxidant Activity. Catalase (a), GSH (b), GST (c), and NO (d) activity in PCM-treated mice. Each value represents mean ± S.E.M (n = 5), analyzed by One Way ANOVA using the LSD test for multiple comparisons. Level of significance is presented as *p < 0.05, **p < 0.01, ***p < 0.001 compared to PCM group and ###p < 0.001 compared to vehicle control group. Mice received a 7-day pretreatment with vehicle, silymarin, and M3F in respective groups. On day 8, hepatotoxicity was induced with PCM in all groups except vehicle control, and samples were collected 24 h post-PCM. Where GSH, Glutathione; GST, Glutathione S-transferase; M3F, test drug; NO, Nitric Oxide; PCM, Paracetamol; SIL, Silymarin.
