Table 2 The most regulated protein in corpus according to volcano plots.

Glutamine synthetase (GLUL)

Enzyme that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine

Fibrillin-2

(FBN2)

Large extracellular matrix glycoprotein serves as a structural component of calcium-binding microfibrils

NADH dehydrogenease ubiquinone iron-sulfur protein 8

(NDUFS8)

Subunit, also known as Complex 1, in electron transport chain at mitochondrial inner membrane

Carboxypeptidase A1 (CPA1)

Proteolytic enzyme, involved in protein catabolism

NADH dehydrogenease ubiquinone oxidoreductase subunit C2

(NDUFC2)

The first and largest complex of the mitochondrial respiratory chain

Phospholipase A2, group 1B

(PLA2G1B)

Enzyme catalyzes the release of fatty acids from glycerol-3-phosphocholines

NADH dehydrogenease ubiquinone oxidoreductase subunit A3

(NDUFA3)

Subunit in electron transport chain at mitochondrial inner membrane

Chymotrypsin-like elastase family member 3 A

(CELA3A)

Enzyme with digestive function, cleaves proteins, cholesterol transport and metabolism

NADH dehydrogenease ubiquinone iron-sulfur protein 6

(NDUFS6)

First enzyme complex in the electron transport chain of mitochondria

Chymotrypsin-like elastase family member 3B

(CELA3B)

Enzyme with digestive function, cleaves proteins, cholesterol transport and metabolism

NADH dehydrogenease ubiquinone oxidoreductase subunit AB1

(NDUFAB1)

Subunit in electron transport chain at mitochondrial inner membrane

Carboxyl ester lipase (CEL)

Contributes to the digestion of dietary lipids

Cytochrome c oxidase subunit 5B

(COX5B)

Mitochondrial respiratory chain (ATP synthesis)

Alpha-amylase 1 (AMY1A)

First step in digestion of dietary starch and glycogen

Fatty acid-binding proteins

(FABP3)

Participate in uptake, intracellular metabolism, and transport of long-chain fatty acids

Chymotrypsin like elastase 2 A

(CELA2A)

Circulating enzyme that trigger insulin secretion and degradation and increases insulin sensitivity

3-oxoacid Coa-transferase 1

(OXCT1, also known as SCOT)

Key enzyme for ketone body catabolism

Pancreatic lipase (PNLIP)

Plays an important role in fat metabolism

Bile salt sulfotransferase 2A1

(SULT2A1)

Enzymes catalyze the sulfate conjugation of hormones, neurotransmitters, drugs, and xenobiotic compounds

Lymphokine-activated killer T-cell-originated protein kinase

(PBK)

Enzyme of serine/threonine kinase related to mitogen-activated protein kinase (MAPKK) family

Matrix metalloproteinase 24

(MMP24)

Enzyme involved in breakdown of extracellular matrix in normal physiological processes

Collagen, type IV, alpha 6

(COL4A6)

Major structural component of basement membranes