Fig. 2
From: InterPAD is a database of drug-drug interaction between phytochemicals and anticancer drugs
A typical InterPAD webpage for drug interaction. The phytochemicals were reported to produce synergistic effects by enhancing drug efficacy, reversing drug resistance, and decreasing drug toxicity, or antagonistic effects by reducing drug efficacy and enhancing drug toxicity. The therapeutic effects of various interaction between phytochemicals and anticancer drugs are then displayed. Using “Artesunate, Fluorouracil” as an example, based on the theory of cold and hot, this theory was fully applied to anticancer drugs, and appropriate medicinal plants were selected within the guidelines to enhance the efficacy of this interaction and decrease the toxicity of fluorouracil.
