Fig. 3 | Scientific Reports

Fig. 3

From: Single cell RNA sequencing analysis of mice hindlimb muscles identifies transcriptional heterogeneity in aging and physical frailty

Fig. 3

Changes in transcriptional profiles of different cell types in specific patterns of relatively healthy aging, age-associated frailty, and age-independent frailty.

(a-c) Bi-directional bar plots showing the number of different genes in 13 cell types in the AIF group with pattern 1 (a), the RHA group with pattern 2 (b) and the AAF group with pattern 3 (c). Green indicates down-regulated genes, and red indicates up-regulated genes. (d-e) GO enrichment analysis of genes down-regulated in B cells in the AIF group with pattern 1 (d) and genes down-regulated in B cells in the AAF group with pattern 3 (e). (f-g) GO enrichment analysis of genes up-regulated in satellite cells in the AIF group with pattern 1 (f) and genes up-regulated in satellite cells in the AAF group with pattern 3 (g). (h-i) GO enrichment analysis of genes down-regulated in mast cells (h) and genes up-regulated in neutrophils (i) in the RHA group with pattern 2.

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