Fig. 1 | Scientific Reports

Fig. 1

From: Thioredoxin regulates T cell proliferation and aggravates the severity of influenza a virus infection

Fig. 1

Research Overview. Employing a multi - omics approach integrating transcriptomics and single - cell transcriptomics, and conducting differential analysis, weighted gene co - expression network analysis (WGCNA), and Friends analysis, we further ascertained that TXN is a crucial target gene that is specifically highly expressed in proliferative T cells. Moreover, we discovered that glutathione metabolism is strongly correlated with the severity of influenza A virus (IAV) infection. During IAV infection, the development of T cells is modulated and altered. Simultaneously, our findings highlight the significant role of T cell death jointly associated with TXN and glutathione metabolism in the progression of IAV.

Back to article page