Fig. 6

IAV Target Gene Mining. A A Venn diagram of the 137 genes shared by the DEGs in GSE101720 and the modules in WGCNA with a correlation of > 0.7 to IAV infection severity. B Four different algorithms were used to calculate the Hub genes and the results were combined to obtain 33 Hub genes. C The cloud-rain diagram of the Friends analysis, where the abscissa represents the FSIM value (the geometric mean of the gene based on the MF, CC, and BP ontologies of Gene Ontology) D Boxplot of gene expression levels of the 10 candidate target genes. E Construct a Venn diagram for the following three entities: the differentially expressed genes of GSE101702, the genes in the key modules (MEmaroon and MEdarkslateblue) within the Weighted Gene Co-expression Network Analysis (WGCNA) of GSE101702, and the differentially expressed genes in the Proliferating CD4 + T cluster of CNP0001102. F Gene expression violin plots of S100A6 in each T cell cluster. G Gene expression violin plots of TXN in each T cell cluster.