Fig. 5

Nomogram construction integrating the MRG prognostic signature and its clinical relevance in the TCGA-KIRC cohort. (A) Comparative analysis of C-indices to evaluate the predictive power of the MRG signature against four alternative prognostic models. (B, C) Cox regression analyses (univariate and multivariate) examining the associations between risk scores (RS) and clinical parameters in the TCGA-KIRC dataset. (D) A nomogram was constructed to predict 1-, 3-, and 5-year overall survival (OS), assigning scores to individual variables and calculating a total score to estimate survival probabilities over time. (E) Calibration plots comparing the nomogram-predicted OS probabilities at 1, 3, and 5 years with observed survival outcomes, demonstrating alignment between predictions and reality. (F-H) ROC curves comparing the 1-, 3-, and 5-year predictive performance of the nomogram, clinical features, and the risk model, highlighting the superior prognostic accuracy of the nomogram in patients with KIRC.