Table 2 Characteristics and patterns of first local therapy (LT).
Total cohort N = 315 (100%) | LT(+)a N = 163 (51.7%) | LT(-) N = 152 (48.3%) | |
|---|---|---|---|
LTb, type | |||
RTxc, n (%) | 80 (49.1) | 80 (49.1) | 0 (0) |
Surgery, n (%) | 68 (41.7) | 68 (41.7) | 0 (0) |
RFAd, n (%) | 4 (2.5) | 4 (2.5) | 0 (0) |
MWAe, n (%) | 0 (0) | 0 (0) | 0 (0) |
SIRTf, n (%) | 2 (1.2) | 2 (1.2) | 0 (0) |
Others, n (%) | 9 (5.5) | 9 (5.5) | 0 (0) |
No. of MTg | |||
Before LT, n, median (range) | 1 (0–6) | 1 (0–6) | NAl |
After LT, n, median (range) | 1 (0–7) | 1 (0–7) | NAl |
Target organ of LT | |||
Bones, n (%) | 73 (44.8) | 73 (44.8) | NAl |
Kidney, n (%) | 7 (4.3) | 7 (4.3) | NAl |
Lung, n (%) | 21 (12.9) | 21 (12.9) | NAl |
Liver, n (%) | 10 (6.1) | 10 (6.1) | NAl |
Lymph nodes, n (%) | 18 (11) | 18 (11) | NAl |
Brain, n (%) | 30 (18.4) | 30 (18.4) | NAl |
Skin, n (%) | 3 (1.8) | 3 (1.8) | NAi |
Othersm, n (%) | 27 (16.6) | 27 (16.6) | NAl |
Total number of administered LTh, n | 189 | 189 | NAl |
Status before LT | |||
Local PD, n (%) | 67 (41.1) | 67 (41.1) | NAl |
Systemic PD, n (%) | 70 (42.9) | 70 (42.9) | NAl |
NEi, n (%) | 26 (16) | 26 (16) | NAl |
Best systemic response after LT | |||
Partial response, n (%) | 11 (6.7) | 11 (6.7) | NAl |
Stable disease, n (%) | 28 (17.2) | 28 (17.2) | NAl |
Progressive diseasej, n (%) | 80 (49.1) | 80 (49.1) | NAl |
Mixed response, n (%) | 6 (3.7) | 6 (3.7) | NAl |
NE due to death, n (%) | 20 (12.2) | 20 (12.2) | NAl |
NE, n (%) | 18 (11.1) | 18 (11.1) | NAl |
ECOGk | |||
Before LT, Median (range) | 0 (0–4) | 0 (0–4) | NAl |
After LT, Median (range) | 1 (0–4) | 1 (0–4) | NAl |
Clinical symptoms | |||
Before LT | |||
Yes, n (%) | 91 (55.8) | 91 (55.8) | NAl |
No, n (%) | 29 (17.8) | 29 (17.8) | NAl |
NE, n (%) | 43 (26.4) | 43 (26.4) | NAl |
After LT | |||
No change, n (%) | 12 (7.4) | 12 (7.4) | NAl |
Improved, n (%) | 49 (30.1) | 49 (30.1) | NAl |
Worsened, n (%) | 16 (9.8) | 16 (9.8) | NAl |
NAl/NE n (%) | 86 (52.7) | 86 (52.7) | NAl |
