Table 7 Co-dominant model table for CRC group (n = 200) tumor stages association with demographic characteristics (age, BMI, sex, and family cancer history) and tumor clinical features (tumor site and vascular infiltration, IBD, and blood TMs) with LINC00511 SNPs rs1558535, rs17780195, and rs9906859 genotypes.

Age (year)

NS

 < 55

54/88 (61)

64/112 (57)

1.00

 > 55

34/88 (39)

48/112 (43)

1.10 (0.51 — 2.41)

NS

BMI (Kg/m²)

NS

 < 25

20/88 (23)

22/112 (20)

1.00

 ≥ 25

68/88 (77)

90/112 (80)

1.66 (0.73 — 3.81)

NS

Sex

NS

Female

67/88 (76)

72/112 (64)

1.00

Male

21/88 (24)

40/112 (36)

1.99 (0.93 — 4.38)

NS

Family History

NS

Negative

68/88 (77)

82/112 (73)

1.00

Positive

20/88 (23)

30/112 (27)

1.63 (0.72 — 3.76)

NS

Tumor site

NS

Ascending Colon

51/88 (58)

45/112 (40)

1.00

Transverse Colon

5/88 (6)

19/112 (17)

4.31 (1.49–12.47)

0.004

Descending Colon

32/88 (36)

48/112 (43)

1.7 (0.93–3.1)

0.05

Vascular infiltration

 < 0.001

Absent

54/88 (61)

42/112 (38)

1.00

Present

34/88 (39)

70/112 (62)

4.00 (1.89 — 8.89)

 < 0.001

IBD History

NS

Negative

40/88 (45)

58/112 (52)

1.00

Positive

48/88 (55)

54/112 (48)

0.33 (0.14 — 0.73)

0.008

CEA (ng/mL)

 < 0.001

 < 4

37/88 (42)

20/112 (18)

1.00

 > 4

51/88 (58)

92/112 (82)

3.55 (1.66 — 7.89)

0.001

CA19-9 (U/mL)

0.017

 < 40

42/88 (48)

35/112 (31)

1.00

 > 40

46/88 (52)

77/112 (69)

2.82 (1.31 — 6.32)

0.009

LINC00511 SNPs

rs1558535 A > T

 < 0.001

AA

24/88 (27)

15/112 (13)

1.00

AT

36/88 (41)

75/112 (67)

3.99 (1.30 — 13.0)

0.018

TT

28/88 (32)

22/112 (20)

0.51 (0.09 — 2.66)

NS

rs17780195 A > G

0.032

AA

58/88 (66)

58/112 (52)

1.00

AG

26/88 (30)

52/112 (46)

2.72 (1.28 — 6.02)

0.011

GG

4/88 (4.5)

2/112 (1.8)

1.24 (0.12 — 11.0)

NS

rs9906859 T > C

NS

TT

16/88 (18)

10/112 (8.9)

1.00

CT

42/88 (48)

62/112 (55)

1.52 (0.41 — 5.88)

NS

CC

30/88 (34)

40/112 (36)

2.66 (0.50 — 15.2)

NS