Table 1 Relationship between baseline plasma levels of CD20+ EVs and outcome measures of AMC-034 trial participants.

From: CD20-bearing extracellular vesicles are associated with prognostic biomarkers of patients with AIDS-NHL

Factor

N

Complete response rate (%)

N

1-Year OS (%)

(95% CI)

1-Year PFS (%)

(95% CI)

CD20+ EVs

< Median

25

64

29

78.2 (57.7–89.6)

68.0 (47.5–81.9)

≥Median

28

64

29

75.7 (55.7–87.6)

75.0 (50.0–88.7)

OR/HR (95%CI)c

 

1.01 (0.33–3.12)

 

1.18 (0.49–2.86)

1.19 (0.53–2.67)

p

 

> 0.999a

 

0.710b

0.675b

  1. Note: Median (IQR) plasma levels of CD20+ EVs were 4.9 (1.6–10.7), N = 58.
  2. aFisher’s exact test.
  3. bLog-rank test.
  4. cOdds Ratio (OR) and 95% confidence interval for complete responses: Hazard Ratio (HR) and 95% confidence interval for overall survival (OS) and progression-free survival (PFS) (unadjusted).
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